colchicine-probenecid (generic name)

It is for joint pain and swelling due to gouty arthritis.
(KOL chi seen; proe BEN e sid)
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What is this medicine?

COLCHICINE; PROBENECID (KOL chi seen; proe BEN e sid) is for joint pain and swelling due to gouty arthritis.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • anemia
  • blood disorders like leukemia or lymphoma
  • having an acute gouty attack
  • heart disease
  • immune system problems
  • intestinal disease
  • kidney disease, stones
  • liver disease
  • low platelet counts
  • stomach problems
  • an unusual or allergic reaction to colchicine, probenecid, other medicines, lactose, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aspirin and aspirin-like drugs
  • clarithromycin
  • erythromycin
  • ketorolac
  • methotrexate
  • topiramate

This medicine may also interact with the following medications:

  • acetaminophen
  • alcohol
  • antibiotics including penicillins, sulfonamides
  • antiviral medicines such as acyclovir, famciclovir, ganciclovir
  • cyclosporine
  • epinephrine
  • lorazepam
  • meclofenamate
  • medicines for diabetes
  • medicines for sleep during surgery
  • methenamine
  • methotrexate
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • pyrazinamide
  • rifampin
  • sodium bicarbonate

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You may need periodic blood checks.

Aspirin and non-steroidal antiinflammatory drugs like ibuprofen can make this medicine less effective. Do not treat yourself for headaches or pain. Ask your doctor or health care professional for advice.

Alcohol can increase the chance of getting stomach problems and gout attacks. Do not drink alcohol.

You may need to be on a special diet while taking this medicine. Check with your doctor. Also, ask how many glasses of fluid you need to drink a day. You must not get dehydrated.

This medicine can interfere with some urine glucose tests. If you use such tests talk with your health care professional.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • back or kidney pain
  • breathing problems
  • dark urine
  • fever, chills, or sore throat
  • numbness or tingling in hands or feet
  • trouble passing urine or change in the amount of urine
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • hair loss
  • headache
  • loss of appetite
  • nausea, vomiting
  • stomach upset

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: April 01, 2009
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