clozapine (generic name)

It is used to treat schizophrenia
(KLOE za peen)
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What is this medicine?

CLOZAPINE (KLOE za peen) is used to treat schizophrenia. This medicine is only used when others have not worked. It has a risk of serious side effects and is only available through a monitoring and dispensing system that includes special doctors, pharmacists, and laboratories. For the first few months of treatment, you will be required to have routine blood testing before your prescription can be refilled.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • being treated for cancer
  • blood disease or disorder, like leukemia
  • constipation, fecal impaction, or a history of an obstruction of the intestine
  • dementia
  • diabetes
  • heart disease
  • history of irregular heartbeat
  • kidney disease
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • low levels of potassium or magnesium in the blood
  • lung or breathing disease, like asthma
  • Parkinson's disease
  • seizures
  • an unusual or allergic reaction to clozapine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. This medicine may be taken with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. Only stop taking this medicine on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you miss your medicine for more than 2 days, you should not restart your medicine at the same dose. Contact your doctor for instructions.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cisapride
  • dofetilide
  • dronedarone
  • fluconazole
  • medicines for treating cancer
  • medicines that lower your chance of fighting infection
  • mesoridazine
  • metoclopramide
  • pimozide
  • posaconazole
  • quinidine
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • alcohol
  • antihistamines for allergy, cough and cold
  • atropine
  • birth control pills
  • caffeine
  • certain antibiotics like ciprofloxacin, erythromycin, mefloquine, moxifloxacin
  • certain medicines for bladder problems like oxybutynin, tolterodine
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for irregular heart beat like amiodarone, encainide, flecainide, propafenone, sotalol
  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • certain medicines for sleep
  • certain medicines for stomach problems like dicyclomine, hyoscyamine
  • certain medicines for travel sickness like scopolamine
  • cimetidine
  • dolasetron
  • enoxacin
  • ipratropium
  • lithium
  • medicines for blood pressure
  • medicines for seizures
  • methadone
  • nicotine
  • pentamidine
  • rifampin or rifabutin
  • skeletal muscle relaxants
  • St. John's Wort
  • tacrolimus
  • terbinafine

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Last Updated: May 07, 2013
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