clorazepate (generic name)

It is used to treat anxiety
(klor AZ e pate)
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What is this medicine?

CLORAZEPATE (klor AZ e pate) is a benzodiazepine. It is used to treat anxiety. It also used to treat alcohol withdrawal and certain types of seizures.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an alcohol or drug abuse problem
  • bipolar disorder, depression, psychosis or other mental health condition
  • glaucoma
  • kidney or liver disease
  • lung or breathing disease
  • myasthenia gravis
  • Parkinson's disease
  • seizures or a history of seizures
  • suicidal thoughts
  • an unusual or allergic reaction to clorazepate, other benzodiazepines, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. If you have been taking this medicine regularly for some time, do not suddenly stop taking it. You must gradually reduce the dose or you may get severe side effects. Ask your doctor or health care professional for advice. Even after you stop taking this medicine it can still affect your body for several days.

A special MedGuide will be given to you by the pharmacist with each new prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 9 years for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • itraconazole

This medicine may also interact with the following medications:

  • medicines for depression, mental problems or psychiatric disturbances
  • prescription pain medicines
  • some medicines for seizures like carbamazepine, phenobarbital, phenytoin, primidone

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Your body can become dependent on this medicine. Ask your doctor or health care professional if you still need to take it.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy and fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

The use of this medicine may increase the chance of suicidal thoughts or actions. Pay special attention to how you are responding while on this medicine. Any worsening of mood, or thoughts of suicide or dying should be reported to your health care professional right away.

Women who become pregnant while using this medicine may enroll in the North American Antiepileptic Drug Pregnancy Registry by calling 1-888-233-2334. This registry collects information about the safety of antiepileptic drug use during pregnancy.

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Last Updated: July 12, 2010
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