cilostazol (generic name)

It is used to treat the symptoms of intermittent claudication
(sil OH sta zol)
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What is this medicine?

CILOSTAZOL (sil OH sta zol) is used to treat the symptoms of intermittent claudication. This condition causes pain in the legs during walking, and goes away with rest. By improving blood flow, this medicine helps people with this condition walk longer distances without pain.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:
  • bleeding disorder or hemophilia
  • history of heart failure, heart attack, or other heart disease
  • an unusual or allergic reaction to cilostazol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • grapefruit juice

This medicine may also interact with the following medications:

  • agents that prevent or treat blood clots like enoxaparin or warfarin
  • aspirin
  • diltiazem
  • erythromycin or clarithromycin
  • omeprazole
  • some medications for treating depression like fluoxetine, fluvoxamine, nefazodone
  • some medications for treating fungal infections like ketoconazole, fluconazole, itraconazole

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may take 2 to 4 weeks for your condition to start to get better once you begin taking this medicine. In some people, it can take as long as 3 months for the condition to get better.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Smoking may have effects on the circulation that may limit the benefits you receive from this medicine. You may wish to discuss how to stop smoking with your doctor or health care professional.

If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • black, tarry stools
  • blood in urine or stools
  • chest pain
  • fast, slow, or irregular heartbeat
  • swelling in the legs or ankles
  • unusual bleeding, bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • nausea, or upset stomach

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: March 30, 2009
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