APAP/dichloralphenazone/isometheptene (generic name)

Migrapap (brand name)

It is used to treat migraine or tension headaches
(a seet a MIN oh fen; dye klor al PHEN a zone; eye soe me THEP teen)
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What is this medicine?

ACETAMINOPHEN; DICHLORALPHENAZONE; ISOMETHEPTENE (a seet a MIN oh fen; dye klor al PHEN a zone; eye soe me THEP teen) is a pain reliever. It is used to treat migraine or tension headaches.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • drink more than 3 alcohol-containing drinks per day
  • glaucoma
  • heart disease or recent heart attack
  • high blood pressure, other blood vessel disorder
  • kidney disease
  • liver disease
  • an unusual or allergic reaction to acetaminophen, dichloralphenazone, isometheptene, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. If taking for migraine headache, do not take more than 5 capsules in any 12-hour period. If taking for tension headache, do not take more than 8 capsules a day. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • bromocriptine
  • disulfiram
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • procarbazine

This medicine may also interact with the following medications:

  • acetaminophen
  • alcohol
  • antacids
  • antihistamines
  • furazolidone
  • isoniazid
  • linezoid
  • medicines for high blood pressure
  • some medicines for depression, anxiety, or psychotic disturbances
  • some medicines for sleep
  • ritonavir
  • warfarin

What should I watch for while using this medicine?

Visit your doctor or health care provider for regular check ups. Tell your doctor if your pain does not go away, if it gets worse, or if you have new or a different type of pain. Do not share this medicine with anyone else.

This medicine contains acetaminophen. Many over the counter medicines also contain acetaminophen as an ingredient. To prevent overdose, read labels carefully. Do not take this medicine with other acetaminophen products.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • difficulty breathing, wheezing
  • fast, irregular heartbeat
  • fever, sore throat
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • nausea
  • upset stomach

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Last Updated: March 10, 2009
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