APAP/dextromethorphan/doxylamine (generic name)

It is used to treat the aches and pains, cough, fever, headache, runny nose and sneezing of a cold
(a set a MEE noe fen; dex troe meth OR fan; dox IL a meen)
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What is this medicine?

ACETAMINOPHEN; DEXTROMETHORPHAN; DOXYLAMINE (a set a MEE noe fen; dex troe meth OR fan; dox IL a meen) is a combination of a pain reliever, a cough suppressant, and an antihistamine. It is used to treat the aches and pains, cough, fever, headache, runny nose and sneezing of a cold. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma, bronchitis, or other lung disease
  • cough that does not go away
  • cough with a lot of phlegm
  • glaucoma
  • if you frequently drink alcohol containing drinks
  • liver disease
  • phenylketonuria
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • trouble passing urine
  • an unusual or allergic reaction to acetaminophen, dextromethorphan, doxylamine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the package label. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • alcohol
  • furazolidone
  • imatinib
  • isoniazid
  • linezolid
  • other medicines for cold, cough or allergy
  • other medicines with acetaminophen
  • procarbazine

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if the pain or cough gets worse or lasts for more than 7 days. Call your doctor if a fever gets worse or lasts for more than 3 days. If a cough does not go away, if a cough comes back, or if it occurs with a rash or headache see your doctor. Also see your doctor if a sore throat lasts more than 2 days or if it occurs with a fever, rash, headache, nausea, or vomiting.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.

If you take too much acetaminophen get medical help right away. Too much acetaminophen can be very dangerous and cause liver damage. Even if you do not have symptoms, it is important to get help right away.

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Last Updated: November 24, 2010
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