Dimethyl sulfoxide (C 2 H 6 OS), or DMSO, is a sulfur-containing organic compound. DMSO occurs naturally in vegetables, fruits, grains, and animal products. DMSO was first synthesized in 1866 as a byproduct of paper manufacturing. Therapeutic interest began in 1963. DMSO was reported to penetrate through the skin and produce analgesia, decrease pain, and promote tissue healing. DMSO is available for both non-medicinal and medicinal uses. The major clinical use of DMSO is to relieve symptoms of interstitial cystitis. Potential toxic effects to the lens of the eye have been reported in animals but no effects have been noted in humans. Topical application has been associated with redness and inflammation of skin, and a garlic-like taste and odor on the breath have been reported. DMSO has been used to treat amyloidosis, diabetic ulcers, extravasation, erosive gastritis, and ischemia prevention in surgical flaps, but well designed clinical trials are lacking. Because of the limited scientific evidence, whether DMSO provides effective treatment of patients with closed head trauma, herpes zoster, tendopathies, and complex regional pain syndrome will require more research.
Chlorophyll is a chemoprotein commonly known for its contribution to the green pigmentation in plants, and is related to protoheme, the red pigment of blood. It can be obtained from green leafy vegetables (broccoli, Brussel sprouts, cabbage, lettuce, and spinach), algae ( Chlorella and Spirulina ), wheat grass, and numerous herbs (alfalfa, damiana, nettle, and parsley). Chlorophyll has been used traditionally to improve bad breath and other forms of body odor including odors of the urine, feces, and infected wounds. More recently chlorophyll has been used to aid in the removal of various toxins via the liver and remains a key compound for improving the function of essential detoxification pathways. Supportive evidence suggests it may be used as an anti-inflammatory agent for conditions, such as pancreatitis as well as exhibiting potent antioxidant and chemoprotective activities. Scientific research has demonstrated it may be an effective therapeutic agent in the treatment of herpes simplex, benign breast disease, chemoprevention, tuberculosis, and rheumatoid arthritis. Type 2 diabetes and obesity are also being explored as areas where chlorophyll can also be used.